くろーばーはうすのおはなし

今年度、最後の慶応大学の先端生命科学研究所の講義。
ラストのお題は、所長の富田勝先生の
「性格の遺伝子：精神活動のバイオサイエンス」

雪が降りしきる中でもなかなかの人出でした。

脳内物質によって、精神活動がどのように左右されているのか。

今回は、かなり込み入った説明が続きました。
話が分かりにくいかもしれません。
興味のない方は、ここで読むのをストップしてください（笑）。

写真は、講義の後に、ちょうど雪が小降りになったので、
研究所と、鶴岡公園の周囲を撮ってみました。
ライトアップしているのは知っていましたが、
ちゃんと見たことがなく、思ったよりもきれいでびっくりしました。
すっかり、観光客気分で、写真を撮っていました。





たとえば、第11番染色体遺伝子には、
新規探索傾向を左右するもの（好奇心の遺伝子・DRD4遺伝子）が
あるんだそうです。

この遺伝子配列の繰り返しが多いと、冒険しやすいというか
興奮しやすいんだそうです。
ちなみに日本人は配列が4回が、米国人は7回が多いそうです。
なんとなく分かるような結果。

また、第17染色体には鬱病になりやすい傾向を左右する遺伝子が
あるそうです（ちなみにセロトニン・トランスポーター関係）。
これがあると、神経質で、不安で慎重な性格になりやすいんだそうです。
これは、なんと日本人には98％、米国人に67％が持っているとか。
これも、うなずけるような…。
まあ、この性格＝悪者ということにはならないと思いますけど。



脳内物質には、アドレナリン、ノルアドレナリン、ドーパミン、セロトニン、
アセチルコリンなど。たくさん見つかっている物質はあるのですが、

富田先生曰く「これらの物質があるから、こういう情動が起こるのか、
これらの情動が起こるから、これらの物質が分泌されるのかは、
まだ、よく分かっていない。」

この講義では、セロトニンにフォーカスが当たっていたので、
簡単に説明すると、セロトニンは、幸福感や満足感を作り出し、
精神を安定させる働きがあり、不安になると、ノルアドレナリンや
ドーパミンを減少させて「癒しの効果」を作り出すと言われてます。

PTSDなど、心に深い傷を受けると、脳の海馬に傷を受けて、
実際に脳が萎縮することが分かってからは、
ちゃんと治療が必要な病気と認められるようになり、
今は、その治療法も少しずつあるようです。

要は、PTSDだと、前頭葉の機能が低下していて、
ちょっとの刺激でも興奮しやすくなり、
不必要に不安傾向を煽るホルモンを分泌してしまうので、

たとえば、SSRIという薬がセロトニンを増やし、
結果的に海馬に新しい細胞ができて、
不安を煽るホルモンを抑えることで、
PTSDを抑えることができるとか。

それから、薬に頼らなくても、
できるだけ幸福感を感じる（セロトニンが出やすい）
状態にいることも、症状を軽くすることができるそうです。




では、芸術などの創作活動や荒行による悟り、などで生まれる
通常では起こりえない精神活動は、脳内物質で
説明できるのか？

一応、極限状態に置かれると、人間の脳の大脳基底核
（脳に入る情報を抑制して、神経を安定化させる装置）が
働かなくなり、情報による刺激が無秩序に脳内に命令を出し始める
そうです。
これが、幻覚と呼ばれるものだったり、創造性のひらめきにつながる。
との説明でした。
肉体的苦痛→脳内麻薬→A-10神経がドーパミン放出→古い脳では深い快感・
新しい脳では創造性（高揚）→限りない至福感→悟り（？）
と、模式されていましたが、どうなんでしょうねえ。



最後に、究極には「幸福の遺伝子」はあるのか？
という話になりました。

「あなたは、幸福ですか？」というアンケートを行ったとき、
面白いことに、「幸福です」と答えた人の割合は、
収入の多寡、年齢や性別、国の貧富差、人種差はなく一定だったそうです。

そして、唯一差が出たのは結婚に関してだそうで
既婚者は未婚者よりも幸福な人が多く、離婚した人は、既婚者・未婚者の両方よりも、
幸福だと答える人が少なかったそうです。

このことから、自分が幸せであると答える人の共通点は、
外向的で楽観的であるという点で
（富田先生流に言うと、セロトニンの分泌が良い人）あり、
良きパートナーに出会えているか、ということのようだ。
と、結論していました。

ということは、私はどこに当てはまるんだろうか？
と、ちょっと悩みました。
性格的にはセロトニンが出やすいとは思いますが、
パートナーを喪失しているというのは、
なかなかハードな状況だと思うのですが…。

よほど富田先生に質問したかったのですが、
やめて、別の質問をしました（笑）。

今日のブログは、すごくわかりにくかったかもしれません。
かなり、自分なりにかみ砕いて、省略してしまっているので、
ここまで、読んでくださった方、ありがとうございます。
もし、質問があったら、コメントしてください（笑）。

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